COSMIC Mission

COSMIC delivers the next generation of systems medicine professionals who successfully combat complex human disorders. We will focus on B-cell lymphoma and rheumatoid arthritis, diseases that originate from abnormal functioning of the adaptive immune system, in particular the germinal center. COSMIC develops and integrates experimental and computational approaches, and establish a unique cross-fertilization between oncology and auto-immunity. 
 
Download: COSMIC Summary
 
  • COSMIC in numbers

    10 Beneficiaries
    7 Partner Organisations
    14 Early Stage Researchers (ESRs)
        -13 PhD students
        -1 Industrial researcher
    5 Companies
    9 European countries
        -NL, FR, SE, UK, IT, ES, DE, CH, EL
    5 Visiting Scientists
    4 External Trainers
    5 Members of External Advisory Board
    1 Ethics Advisor
  • COSMIC Research Background

    Systems Medicine

    One of the key question in systems biology is how biological systems (e.g., cells, molecular networks, germinal center) operate upon interaction with their external environment. Answering this question will generate knowledge about the dy­namics of complex systems and quantitative and explanatory computer models based on ex­perimental data.

    Systems medicine implements systems biology approaches in medical research and practice. This involves iterative and reciprocal feedback between clinical investigations and practice with computational, statistical and mathematical multiscale analysis and modelling of pathogenetic mechanisms, disease progression and remission, treatment responses, and adverse events as well as disease prevention at the individual patient level.

    Systems medicine aims at a measurable improvement of patient health through systems-based approaches and practice.

    Source: CASyM
    See also: EASyM
    Further reading: Schmitz, U., and Wolkenhauer, O. eds. (2016). Systems Medicine (New York: Springer)

    Adaptive immunity
    Germinal Center
    B-cell lymphoma
    Rheumatoid Arthritis
    Computational modelling
  • COSMIC Systems Medicine

    Through collaboration with existing systems medicine initiatives (e.g. EASyM, ISBE) COSMIC researchers contribute to systems medicine infrastructure and best practices that reduce time and costs to address clinical needs.

    At the same time this will promote Europe’s position in the health domain.
  • COSMIC Training

    An important aim of the Marie Sklodowska-Curie Action European Training Network (ETN) is to train young researchers (Early Stage Researchers, ESRs) with multi-disciplinary and multi-sectorial scientific and transferable skills required in systems medicine and translational medicine (WP2).

    COSMIC delivers 14 highly skilled systems medicine professionals who are able to address and solve complex clinical questions and to shape the next generation of systems medicine scientists.

 

COSMIC kickoff meeting. An impression

 
8-9 February, 2018
Amsterdam
 
COSMIC officially started 1st of January 2018. To further define the research projects and the training for the fellows Beneficiaries and the Partner Organisations of the consortium gathered in Amsterdam for a two-day kickoff meeting. During the first day both the Beneficiaries and Partner Organisations participated. On the second day the research programme was further discussed with Beneficiaries only.
 Kickoff 19
Part of the COSMIC consortium.   From left to right: Olivier Gandrillon (Inria), Stefano Casola (IFOM), Michael Berthold (KNIME), Sebastian Binder (replacing Michael Meyer-Hermann; HZI), Daniel Primo (replacing  Joan Ballesteros; Vivia Biotech), Niek de Vries (AMC), Judith Farres (Anaxomics), Jeroen Engelberts (SURFsara), Martin Turner (Babraham Institute), Fabien Crauste (Inria), Maria Martinez (IBM), Kostas Stamatopoulos (CERTH), Antoine van Kampen (AMC), Laurian Jongejan (AMC) Jeroen Guikema (AMC), Rikard Holmdahl (Karolinska Institutet), Eva van Ingen (Elevate Health), Malin Hultqvist (Redoxis), Eva Brinkman (Science Matters). Not on picture but present: Tjitske Bezema (Immunowell), Celia van Gelder (DTL).
 
During the first day the status and the overall aim of the project were presented by Antoine van Kampen to also clariy the project to the Partner Organisations who do not all have a background in immunology and/or computational sciences. Importantly, we are currently recruiting the fellows and further effort is needed to define their (initial) research project, and to prepare the training during their first year (2018) and during the workshops of the First Annual Meeting (beginning of 2019). The first few deliverables have already been fulfilled (e.g., Website, Social Media, start with outreach, etc) while other deliverables (e.g., Data management plan, Dissemination plan, Ethics) are due for this year. Work to do!
 
Kickoff 8
Antoine van Kampen (AMC) explaining the germinal center reaction.
 
Subsequently, the Work Package (WP) Leaders gave an introduction to the research questions in their WPs and the collaborations that they forsee between the WPs. Jeroen Guikema introduced the B-cell lymphoma WP (WP3). Rikard Holmdahl introduced the Rheumatoid Arthritis WP (WP4). Finally, Sebastian Binder introduced the Computational Disease Models WP (WP5). The WP leaders gave an general introduction about B-cell lymphoma (BCL), rheumatoid arthritis (RA), and computational modelling to facilitate a better communication between the project participants. 
 
Kickoff 11
Jeroen Guikema (WP3 leader; AMC) introducing different types of B-cell lymphoma.
 
 
Kickoff 12
Rikard Holmdahl (WP4 leader; Karolinska Institutet) introducing the different phases in rheumatoid arthritis .
  
Kickoff 21
Sebastian Binder (replacing Michael Meyer-Hermann; WP5 leader; HZI) introducing different computational modelling approaches.

 

After lunch each of the Principal Investigators presented in 10 minutes (a huge challenge!!) the first-year research project of their fellow. These presentations prepared the stage for the second day during which the Beneficiaries discussed these projects and further collaborations within/between the WPs in more detail in smaller groups. 

  

Kickoff 15
Getting to know eachother during lunch.
 
Kickoff 24
Kostas Stamatopoulos (WP3; CERTH) presenting BCR signalling in B-cell lymphoma.
 
Kickoff 28
Niek de Vries (WP4; AMC) explaining (the clinical onset of) rheumatoid arthritis.
 
Kickoff 39

Maria Martinez (WP5; IBM) explaining her computational approach to address BCL and RA.

 Kickoff 47

Jeroen Engelberts (Partner Organisation; SURFsara) presenting computational facilities at SURFsara.

 Kickoff 48

Eva Brinkman (Partner Organisation; Science Matters) introducing the contribution of Science Matters.

 

This concluded the first day after which we went for dinner to continue discussion. During the second day we proceeded discussions in smaller groups (per Work Package) and concluded with a round table discussion to wrap-up the kick-off. 

 

During the kickoff all participants received a coffee mug (the first COSMIC merchandise!!). 

 Koffiemok2 Koffiemok1   koffiemok3

 

In addition, the first COSMIC video was launched. See our COSMIC YouTube channel

COSMIC NEWS

29 April 2018 3056

EASyM conference

2nd Conference of the European Association of Systems Medicine (EASYM) This conference is…
27 January 2018 2710

Andien Vaes: new controller

New controller: Andien Vaes. Andien Vaes (AMR) takes over the tasks of Don van Velzen.…
23 December 2017 761

Biotecture becomes Science Matters

Biotecture becomes Science Matters Our Partner Organisation Biotecture changed their name…

COSMIC Highlights

22 February 2019 227

CERTH Highschool students

Highschool students at CERTH Rerun by popular demand. Bastien of PLANT.ID did so well…
11 February 2018 1680

COSMIC Coffee Mug

First COSMIC Merchandise During the kickoff meeting (8-9 February) all participants…
11 February 2018 906

Kickoff meeting

COSMIC kickoff meeting. 8-9 February, 2018 Amsterdam COSMIC officially started 1st of…

Events

06 May 2018 659

5th European Congress of Immunology

5th European Congress of Immunology 2-5 september 2018 | Amsterdam RAI Exhibition and…
29 April 2018 1132

EASyM 2nd conference

2nd Conference of the European Association of Systems Medicine (EASYM) 7 - 9 November…
16 March 2018 1607

Workshop Applying bioinformatics and data science competency frameworks to ELIXIR Training

Workshop Applying bioinformatics and data science competency frameworks to ELIXIR…

 

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    Project coordination

    Prof. dr. A.H.C. van Kampen (Antoine)
    Bioinformatics Laboratory
    E: a.h.vankampen at amc.uva.nl
    P: +31 20 5667096

    Project management:
    Dr. Laurian Jongejan
    Department of Experimental Immunology
    E: l.zuidmeer at amc.uva.nl
    P: +31 20 5666819

    The Netherlands
    Academic Medical Center, University of Amsterdam

    Marie Skłodowska-Curie Actions

    The Marie Skłodowska-Curie actions (MSCA), named after the double Nobel Prize winning Polish-French scientist famed for her work on radioactivity, support researchers at all stages of their careers. One type of action is the European Training Network (ETN) aimed at joint research training by partners from academia, industry, and other organisation. ETNs facilitate the the researcher to experience different sectors and develop their transferable skills by working on joint research projects.

    H2020

    COSMIC is a European Training Network funded from the European Union's Horizon 2020 research and innovation programme under grant agreement No 765158.









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